Results
| PMID | 16963127 |
| Gene Name | IL18 |
| Condition | Endometriosis |
| Association |
Associated |
| Sex | Female |
| Associated genes | IL-18 |
| Other associated phenotypes |
Endometriosis |
|
J Reprod Immunol. 2006 Dec;72(1-2):108-17. Epub 2006 Sep 11. Luo, Qiong| Ning, Weixuan| Wu, Yanting| Zhu, Xiaoming| Jin, Fan| Sheng, Jianzhong| Huang, Hefeng Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310006, China. OBJECTIVE: This study has investigated the expression of interleukin (IL)-18 in the eutopic and ectopic endometrium of women with endometriosis and the role of IL-18 on the pathogenesis of endometriosis. METHODS: Endometriotic tissue specimens and endometrium specimens were obtained from patients with endometriosis. IL-18 protein was determined by immunohistochemical analysis. Expression levels of IL-18 mRNA were analyzed by reverse transcriptase (RT)-PCR. RESULTS: IL-18 was detected in the glandular epithelial and stromal cells of eutopic and ectopic endometrium. RT-PCR analysis showed that endometrial IL-18 mRNA expression levels were significantly higher at the secretory phase than the proliferative phase in normal women, but not in patients with endometriosis. IL-18 mRNA expression levels were lower in the ectopic endometrium than in the eutopic endometrium of women with endometriosis. IL-18 mRNA levels in both ectopic and eutopic endometrium of patients with endometriosis were lower than in endometrium of women without endometriosis. CONCLUSION: Ectopic and eutopic endometrial IL-18 was down-regulated in women with endometriosis, suggesting that IL-18 might play a pathogenic role in the formation of endometriosis. Mesh Terms: Adult| Choristoma/*immunology| Endometriosis/*immunology| Endometrium/chemistry/*immunology| Female| Humans| Immunohistochemistry| Interleukin-18/analysis/genetics/*metabolism| RNA, Messenger/analysis/metabolism|DA 2007/01/24 09:00 |
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